# Proton Pump Inhibitors --- **Proton pump inhibitors** are a class of [[medicine]] that reduce the production of [[stomach acid]] by inhibiting the proton pumps that produce it. They're used to treat conditions such as [[peptic ulcer disease|peptic ulcers]] or [[GERD]]. ## Mechanism of Action Binds to enzyme that prevents transports of hydrogen ions into gastric lumen, blocking the production of [[stomach acid|HCl]]. ## Adverse Reactions These meds are usually tolerated well, but there is some risk for [[healthcare associated infection|C. diff]] (i.e. diahrrea) from a loss of good gut bacteria. Can also interfere with [[magnesium]] absorption. ## Examples - **Omeprazole** (brand name: **Prilosec**) - PO on an empty stomach - **Pantoprazole** (brand name: **Protonix**) - PO or IVP 4mg/mL over at least 2 minutes ___